Citrulline depletion by ass1
WebApr 15, 2024 · Argininosuccinate synthase (ASS1) is a ubiquitous enzyme in mammals that catalyzes the formation of argininosuccinate from citrulline and aspartate. ASS1 genetic … WebFeb 3, 2024 · Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses Youxiang Mao, Di Shi, Gen Li, Peng Jiang Pages 527-541.e7 View PDF Article preview Research articleOpen archive The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis
Citrulline depletion by ass1
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WebBackground: Citrullinemia type I (CTLN1) is a rare autosomal recessive disorder of the urea cycle caused by a deficiency in the argininosuccinate synthetase (ASS1) enzyme due to mutations in the... WebHA-ASS1 or vector control were used for immunoprecipitation with anti-HA antibody. Immunoprecipitants were analyzed by immunoblotting. (F) Production of murine …
WebJan 10, 2024 · Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses January 2024 Authors: Youxiang Mao Di Shi Gen Li … WebFeb 3, 2024 · Citrulline depletion during inflammatory stimulation is largely due to a STAT1-mediated boost in ASS1 expression and JAK2-induced ASS1 phosphorylation. …
WebFeb 3, 2024 · Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses Youxiang Mao, Di Shi, Gen Li, Peng Jiang Mao et al. showed that phosphorylation and transcriptional upregulation of ASS1 mediated by JAK2 and STAT1, respectively, to deplete citrulline is essential for proinflammatory … WebCitrullinemia, type I is an inherited (genetic) condition that prevents the body from removing ammonia properly. Ammonia is a waste product produced when the body breaks down …
WebThe enzyme argininosuccinate synthetase-1 (ASS1) combines citrulline and aspartate in the cytosol of hepatocytes to generate argininosuccinate. Citrulline and aspartate leave …
WebJun 7, 2024 · The recycling of citrulline by argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase (ASL) is crucial to maintain arginine availability and nitric oxide … how far has mars rover traveledWebJun 25, 2015 · Tumor cells that lack ASS1 are therefore dependent on exogenous arginine, which in normal circumstances is available from the extracellular environment. 4-6 However, ASS1-negative tumor cells are potentially vulnerable to systemic arginine depletion, having no means to synthesize their own. how far has russia goneWebBackground: The recycling of citrulline by argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase (ASL) is crucial to maintain arginine availability and nitric oxide … how far has nasa gone in spaceWebFeb 23, 2016 · In ASS1 negative tumors, nutrient stress leads to a cumulition of endoplasmic ... cell line (BRL). It was subsequently determined that the mycoplasma-derived ADI was responsible for this effect. The depletion of arginine by ADI to citrulline and ammonia has been studied. Like native arginase, the small molecular weight ADI protein … hieroglyphics sowetoWebFeb 3, 2024 · Blockage of ASS1-mediated citrulline depletion suppresses the host defense against bacterial infection in vivo. We therefore define a central role for ASS1 in … how far has mars rover curiosity traveledWebAug 31, 2024 · ASS1 catalyzes the formation of argininosuccinate from citrulline and aspartate and is a key component in the liver urea cycle (UC). ... ASS1 depletion under … hieroglyphics soundsWebAug 3, 2024 · We examined the expression of two major enzymes involved in arginine depletion and replenishment, namely arginase ARG2 and argininosuccinate synthase … hieroglyphics souls of mischief