Cullin-ring ligase
WebJan 1, 2005 · The common catalytic core of cullin–RING ligases (CRLs), which consists of a RING protein and a cullin-family member, defines this modular class of … WebJun 10, 2016 · Cullin-RING ligases (CRLs), the largest E3 ubiquitin ligase family, promote ubiquitination and degradation of various cellular key regulators involved in a broad array of physiological and pathological processes, including cell cycle progression, signal transduction, transcription, cardiomyopathy, and tumorigenesis.
Cullin-ring ligase
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WebCullin-RING ubiquitin ligases (CRLs) represent the largest superfamily of multi-subunit E3s conserved in all eukaryotes. Soon after the discovery of these important ubiquitin ligase machineries, structural studies have made tremendous contributions to our … WebDec 15, 2015 · CRLs (Cullin-RING E3 ubiquitin ligases) are the largest E3 ligase family in eukaryotes, which ubiquitinate a wide range of substrates involved in cell cycle regulation, signal transduction, transcriptional regulation, DNA damage response, genomic integrity, tumor suppression and embryonic development.
WebFeb 18, 2024 · Cullin-RING E3 ubiquitin ligases (CRLs) direct protein degradation to impact a myriad of physiological and pathological processes including cancer. This work reports the small-molecule compounds 33-11 and KH-4-43 as inhibitors of E3 CRL4 with anticancer potential. These compounds have provided an opportunity for developing tool … WebAmong them, RING E3 ubiquitin ligases which are the most abundant E3 ubiquitin ligases contribute to diverse cellular processes. The multisubunit cullin-RING ligases (CRLs) are the largest family of RING E3 ubiquitin ligases with tremendous plasticity in substrate specificity and regulate a vast array of cellular functions.
WebCullin-RING ligase 5 (CRL5) is a multi-protein complex and consists of a scaffold protien cullin 5, a RING protein RBX2 (also known as ROC2 or SAG), adaptor … WebMar 13, 2024 · Developing a better understanding of the contributions of each Cullin-Ring Ligase complex in cellular homeostasis remains a challenging task. A large portion of …
WebCullin-RING Ligase Regulation by the COP9 Signalosome: Structural Mechanisms and New Physiologic Players Feng Rao, Hong Lin, Yang Su Pages 47-60 Coordinated Actions Between p97 and Cullin-RING Ubiquitin Ligases for Protein Degradation Wenbo Shi, Ran Ding, Pei Pei Zhou, Yuan Fang, Ruixi Wan, Yilin Chen et al. Pages 61-78
WebThe cullin-RING ligases (CRLs) are a highly polymorphic E3 collection composed of a cullin backbone onto which binds carriers of activated Ub and a diverse assortment of adaptors … tss1500WebApr 7, 2024 · E3s can be classified in three main types, depending on the presence of characteristic domains: the homologous to E6-AP C-terminus (HECT), really interesting new gene (RING), and RING-between-RING (RBR) domains [ 8 ]. The RING-type ubiquitin ligase family represents the most abundant human E3s with over 600 members [ 9 ]. phish the curtainWebCullin 3 (CUL3) is the scaffold of Cullin3 Ring E3-ligases (CRL3s), which use various BTB-adaptor proteins to ubiquitinate numerous substrates targeting their proteasomal … phish television appearancesWebAbstract. SCF Cdc4 (S kp1, C dc53/cullin, F-box protein) defines a family of modular ubiquitin ligases (E3s) that regulate diverse processes including cell cycle, immune … phish telluride pictureWebCullin 3 (CUL3) is the scaffold of Cullin3 Ring E3-ligases (CRL3s), which use various BTB-adaptor proteins to ubiquitinate numerous substrates targeting their proteasomal degradation. CUL3 mutations, responsible for a severe form of familial hyperkalemia and hypertension (FHHt), all result in a deletion of exon 9 (amino-acids 403-459) (CUL3-∆9). phish teams backgroundphish the garden state arts center holmdel njWebThe general catalytic core of cullin-RING ligases (CRLs) is comprised of a RING protein and a cullin-family member, which delimits this modular category of RING ubiquitin ligase. NEDD8 (Nd8, neural precursor cell expressed developmentally down-regulated protein 8), as a ubiquitin-like modifier, efficiently activates Cullins by the covalent ... phish the gorge 1998