Web20 jul. 2024 · A kinase called heme-regulated inhibitor (HRI) could be a therapeutic target for sickle cell disease (SCD) and some forms of β-thalassemia, according to researchers. The team found that reducing the activity of HRI (also known as EIF2AK1) can boost the production of fetal hemoglobin (HbF). Ger WebThe heme-regulated inhibitor (HRI) is a heme-sensing kinase that regulates mRNA translation in erythroid cells. In heme-deficiency, HRI is activated to phosphorylate …
ONC201 kills solid tumor cells by triggering an integrated stress ...
WebAuthor: Alvarez-Castelao, B. et al.; Genre: Journal Article; Published in Print: 2024-04-24; Open Access; Keywords: heme-regulated inhibitory kinase neuroscience protein degradation protein synthesis proteostasis rat; Title: The switch-like expression of heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition Web16 nov. 2006 · HRI, the h eme-r egulated i nhibitor of translation, was discovered in reticulocytes under the conditions of iron and heme deficiencies, which cause inhibition … raili korhonen
Heme‐regulated eIF2α kinase (HRI) is required for translational ...
WebThe purified heme-regulated kinase (HRI) undergoes autophosphorylation; at least 3 mol of phosphate can be incorporated per HRI subunit (Mr 80,000). The phosphorylation of HRI, its eIF-2 alpha kinase activity, and its ability to inhibit protein synthesis are diminished by hemin (5 microM) and increased by N-ethylmaleimide (MalNEt). Web5 jul. 2024 · ER kinase), and HRI (heme-regulated inhibitor). PKR detects viral double-stranded RNA (dsRNA); GCN2 senses uncharged t RNAs that accumulate. in cells lacking free amino acids (AA) (1, 2); PERK. Web22 mei 2024 · HRI mediates the cellular confinement and killing of virulent L. monocytogenes. heme-regulated inhibitor (HRI), protein kinase R (PKR), PKR-like endoplasmic reticulum kinase, (PERK) and general control non-depressible 2 (GCN2) are sufficient for the integrated stress response; there are no additional eIF2alpha kinases in … raili koskinen