WebJul 1, 2024 · Discovery of SARS-CoV-2 RNA-dependent-RNA-polymerase (RdRp) Inhibitor from Sambiloto (Andrographis paniculata) Based on Molecular Docking and ADMET … WebApr 28, 2024 · Remdesivir resistance. The nucleoside analog remdesivir (RDV) is a mainstay of treatment for SARS-CoV-2 infection; however, it is not clear how SARS-CoV-2 could …
Repurposing FDA-approved drugs to fight COVID-19 using
WebOct 11, 2024 · RNA-dependent RNA polymerase (RdRp),3,4 which is the object of the present investigation. In detail, SARS-CoV-2 is a positive RNA virus, which for its proliferation requires RdRp, a key enzyme that regulates the replication and transcription of the viral genome. For this reason, RdRp has become the validated target for the WebDec 3, 2024 · The RNA-dependent RNA polymerase (RdRp) is an essential enzyme for the viral replication process, catalyzing the viral RNA synthesis using a metal ion-dependent mechanism. In recent years, RdRp has emerged as an optimal target for the development of antiviral drugs, as demonstrated by recent approvals of sofosbuvir and remdesivir against … normal size school backpack
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WebHere we applied computational approaches to examine if some polyphenols can also inhibit RNA polymerase (RdRp) in SARS-CoV-2, and we identified some better candidates than remdesivir, the FDA-approved drug against RdRp, in terms of estimated binding affinities. The proposed compounds will be further examined to develop new treatments for COVID … WebRepurposing FDA-approved drugs to fight COVID-19 using in silico methods: Targeting SARS-CoV-2 RdRp enzyme and host cell receptors (ACE2, CD147) through virtual screening and molecular dynamic simulations Inform Med Unlocked. 2024;23:100541. doi: 10.1016/j.imu.2024.100541. Epub 2024 Feb 25. Authors WebSep 27, 2016 · The alignment was performed by CLUSTAL X and highlighted with the GeneDoc application. The conserved motifs of RdRp in dsRNA viruses are indicated by Roman numerals; (B) Phylogenetic analysis of the viral RdRp amino acid sequences of CgCV1. The phylogenic tree was constructed using the neighbor-joining method (1000 … normal size refrigerator freezer capacity