Structure of uricase
WebFeb 25, 2024 · Urate oxidase (uricase EC 1.7.3.3; UOX) is a functional tetramer that plays an important role in purine degradation pathway by catalyzing the oxidative degradation of uric acid to allantoin in the absence of any cofactor or metal ions [ 4 – 6 ]. WebSep 3, 2014 · Bacillus fastidious uricase (BF uricase) containing 322 amino acid residues exhibited high stability under physiological conditions. Its crystal structure was solved to …
Structure of uricase
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WebThe potential of urate oxidase (uricase) for clinical use has been highlighted because of its role in lowering the blood uric acid levels for the treatment of tumor lysis syndrome. In the present study, the codon-optimized synthetic gene of Aspergillus flavus uricase was fused to the Mxe GyrA intein and chitin-binding domain. WebNodulin-35 (N-35), a subunit of nodule-specific uricase (uricase II) of soybean ( Glycine max ), is shown to be preferentially synthesized on free polysomes during nodule development …
WebStructure-Based Immunogenicity Prediction of Uricase from Fungal (Aspergillus flavus), Bacterial (Bacillus subtillis) and Mammalian Sources Using Immunoinformatic Approach. … WebFeb 14, 2024 · Structural highlights. Uricase is mainly located in the liver where it forms an elctron dense crystalline core in peroxisomes. It is a tetramer of identical subunits each …
WebJun 28, 2024 · The structure of K12C–E286C AgUricase was initially solved by molecular replacement using Phenix.phaser with the wild-type AgUricase structure (PDB entry: … WebMar 20, 2015 · Crystal structure of BF uricase was thus determined by X-ray diffraction. Surprisingly, our newly solved crystal structure contained the atomic coordinates for all of a total of 18 C-terminus residues in each subunit after the intersubunit antiparallel β-sheet.
WebDefine uricase. uricase synonyms, uricase pronunciation, uricase translation, English dictionary definition of uricase. n an enzyme found in organisms from bacteria to …
Urate oxidase is mainly localised in the liver, where it forms a large electron-dense paracrystalline core in many peroxisomes. The enzyme exists as a tetramer of identical subunits, each containing a possible type 2 copper-binding site. Urate oxidase is a homotetrameric enzyme containing four identical … See more The enzyme urate oxidase (UO), uricase or factor-independent urate hydroxylase, absent in humans, catalyzes the oxidation of uric acid to 5-hydroxyisourate: Uric acid + O2 + H2O → 5-hydroxyisourate + H2O2 5 … See more Urate oxidase is the first enzyme in a pathway of three enzymes to convert uric acid to S-(+)-allantoin. After uric acid is converted to 5 … See more Urate oxidase is formulated as a protein drug (rasburicase) for the treatment of acute hyperuricemia in patients receiving chemotherapy. … See more • 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase See more Urate oxidase is found in nearly all organisms, from bacteria to mammals, but is inactive in humans and several other great apes, having … See more UO is also an essential enzyme in the ureide pathway, where nitrogen fixation occurs in the root nodules of legumes. The fixed nitrogen is … See more infect v tabletWeb8 rows · May 5, 2007 · RCSB PDB - 2YZE: Crystal structure of uricase from Arthrobacter globiformis. Biological Assembly ... infect you with their lightheartedWebJan 15, 2010 · Uricase-containing lipid vesicles (UOXLVs) were prepared by reverse-phase evaporation method with high efficiency and the characteristics of UOXLVs were described. The average size and zeta potential of UOXLVs obtained by the optimized formulation were 205.47 nm and -37.33 mV, respectively. infect vs toxicWebSep 1, 2009 · Uricase-containing lipid vesicles (UOXLVs) were prepared by reverse-phase evaporation method with high efficiency and the characteristics of UOXLVs were described. The average size and zeta... infect virus githubWebDec 21, 2016 · Urate oxidase (uricase) is a homotetrameric enzyme composed of four identical 34 kDa subunits [ 1 ]. This enzyme initiates a series of reactions that convert uric … infected arm powerlistingWebUricase is a new drug with uric acid-lowering effects, also known as Uricase and Urate Oxidase, which is characterized with a function of promotion of the breakdown of uric … infect your friends and loved ones summaryWebApr 8, 2024 · Of note, uricase is only found in animals, but not in humans. Generally, a third of the daily excretion of uric acid is through the intestine, while the other two-thirds is through the kidney. ... .1, and 26.2 minutes displayed similar UV-VIS spectra (A), which indicated these compounds may share a similar chemical structure and maximum ... infect villager